TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer
RMA Linger, AK Keating, HS Earp… - Advances in cancer …, 2008 - Elsevier
Tyro‐3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (RTKs)
characterized by a conserved sequence within the kinase domain and adhesion molecule‐
like extracellular domains. This small family of RTKs regulates an intriguing mix of
processes, including cell proliferation/survival, cell adhesion and migration, blood clot
stabilization, and regulation of inflammatory cytokine release. Genetic or experimental
alteration of TAM receptor function can contribute to a number of disease states, including …
characterized by a conserved sequence within the kinase domain and adhesion molecule‐
like extracellular domains. This small family of RTKs regulates an intriguing mix of
processes, including cell proliferation/survival, cell adhesion and migration, blood clot
stabilization, and regulation of inflammatory cytokine release. Genetic or experimental
alteration of TAM receptor function can contribute to a number of disease states, including …