Neurological impairment in rats after subarachnoid hemorrhage—a comparison of functional tests

SC Thal, K Meßmer, R Schmid-Elsaesser… - Journal of the …, 2008 - Elsevier
Functional outcome has become a key parameter for the determination of the efficacy of
therapeutic interventions. Unfortunately, functional tests are not established for filament
perforation induced subarachnoid hemorrhage (SAH). Therefore, we evaluated generally
applied functional tasks for their potential to discriminate between various degrees of
neuronal damage. Rats were subjected to SAH by an endovascular filament and were
randomly assigned to controls treated with 0.9% NaCl, moderately neuroprotective therapy …