Investigation of the pathophysiology of injury after intracerebral hemorrhage (ICH) requires a
reproducible animal model. While ICH accounts for 10-15% of all strokes, there remains no
specific effective therapy. The autologous blood injection model in mice involves the
stereotaxic injection of arterial blood into the basal ganglia mimicking a spontaneous
hypertensive hemorrhage in man. The response to hemorrhage can then be studied in vivo
and the neurobehavioral deficits quantified, allowing for description of the ensuing …