Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols
MO Kane, E Anselm, YD Rattmann, C Auger… - Vascular …, 2009 - Elsevier
Regular intake of moderate amounts of beverages rich in polyphenols such as red wine is
associated with a protective effect on the vascular system, in part, by increasing the
endothelial formation of nitric oxide (NO), a major vasoprotective factor. Since estrogens are
potent inducers of NO formation and polyphenols have been shown to have phytoestrogen
properties, we determined whether estrogen receptors mediate the stimulatory effect of red
wine polyphenols (RWPs) on the endothelial formation of NO using isolated rat aortic rings …
associated with a protective effect on the vascular system, in part, by increasing the
endothelial formation of nitric oxide (NO), a major vasoprotective factor. Since estrogens are
potent inducers of NO formation and polyphenols have been shown to have phytoestrogen
properties, we determined whether estrogen receptors mediate the stimulatory effect of red
wine polyphenols (RWPs) on the endothelial formation of NO using isolated rat aortic rings …