[HTML][HTML] Notch signaling and new therapeutic options in liver disease

CM Morell, M Strazzabosco - Journal of hepatology, 2014 - Elsevier
Notch signaling is a crucial determinant of cell fate decision during development and
disease in several organs. Notch effects are strictly dependent on the cellular context in
which it is activated. In the liver, Notch signaling is involved in biliary tree development and
tubulogenesis. Recent advances have shed light on Notch as a critical player in liver
regeneration and repair, as well as in liver metabolism and inflammation and cancer. Notch
signaling is finely regulated at several levels. The complexity of the pathway provides …