Misreading of ribonucleic acid code words induced by aminoglycoside antibiotics: the effect of drug concentration
J Davies, BD Davis - Journal of Biological Chemistry, 1968 - ASBMB
Aminoglycoside antibiotics were found to vary widely in the effect of variation in their
concentration on the degree of misreading of synthetic RNA messengers. Thus, neomycin,
kanamycin, and gentamicin showed a 3-to 5-fold increase in the level of misreading as the
drug concentration was raised from 10− 6 to 10− 4 M. This effect suggests that each of these
drugs may act on more than one site. Observed changes in the qualitative nature of the
misreading at different concentrations support this inference, which is also consistent with …
concentration on the degree of misreading of synthetic RNA messengers. Thus, neomycin,
kanamycin, and gentamicin showed a 3-to 5-fold increase in the level of misreading as the
drug concentration was raised from 10− 6 to 10− 4 M. This effect suggests that each of these
drugs may act on more than one site. Observed changes in the qualitative nature of the
misreading at different concentrations support this inference, which is also consistent with …