Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with severe anemia: the TOTAL randomized …
A Dhabangi, B Ainomugisha, C Cserti-Gazdewich… - Jama, 2015 - jamanetwork.com
Importance Although millions of transfusions are given annually worldwide, the effect of red
blood cell (RBC) unit storage duration on oxygen delivery is uncertain. Objective To
determine if longer-storage RBC units are not inferior to shorter-storage RBC units for tissue
oxygenation as measured by reduction in blood lactate levels and improvement in cerebral
tissue oxygen saturation among children with severe anemia. Design, Setting, and
Participants Randomized noninferiority trial of 290 children (aged 6-60 months), most with …
blood cell (RBC) unit storage duration on oxygen delivery is uncertain. Objective To
determine if longer-storage RBC units are not inferior to shorter-storage RBC units for tissue
oxygenation as measured by reduction in blood lactate levels and improvement in cerebral
tissue oxygen saturation among children with severe anemia. Design, Setting, and
Participants Randomized noninferiority trial of 290 children (aged 6-60 months), most with …