Placental deficiency of interleukin-10 (IL-10) in preeclampsia and its relationship to an IL10 promoter polymorphism

A Makris, B Xu, B Yu, C Thornton, A Hennessy - Placenta, 2006 - Elsevier
The placenta is pivotal in the acceptance of the feto-placental unit by the maternal immune
system. Imbalance at the maternal–fetal interface of tissue pro-and anti-inflammatory
cytokines may be partly involved in disease causation. Previous work has shown conflicting
levels of IL-10. IL-10 levels have been shown to increase, decrease, or remain unchanged
in women with preeclampsia. This study examines the difference in serum and placental IL-
10 expression in women with preeclampsia and investigates if the IL10 (− 1082) A promoter …