A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system
MMJ Polfliet, PH Goede… - Journal of …, 2001 - Elsevier
The perivascular (PVM) and meningeal (MM) macrophages form a distinct population of
resident CNS cells, selectively expressing the mature macrophage marker ED2 in the rat. In
order to elucidate the role of the PVM and MM in rats during normal functioning of the brain
and pathology, we have developed a strategy employing a single intraventricular injection of
clodronate liposomes. This resulted in a complete depletion of the PVM and MM. Clodronate
liposomes did not deplete the microglial cells. In other parts of the body, a temporal and mild …
resident CNS cells, selectively expressing the mature macrophage marker ED2 in the rat. In
order to elucidate the role of the PVM and MM in rats during normal functioning of the brain
and pathology, we have developed a strategy employing a single intraventricular injection of
clodronate liposomes. This resulted in a complete depletion of the PVM and MM. Clodronate
liposomes did not deplete the microglial cells. In other parts of the body, a temporal and mild …