Tissue microarray analysis of hMSH2 expression predicts outcome in men with prostate cancer
A Prtilo, FS Leach, R Markwalder, A Kappeler… - The Journal of …, 2005 - Elsevier
PURPOSE:: Mismatch repair genes are responsible for the coordinated correction of
misincorporated nucleotides formed during DNA replication. Mismatch repair expression is
altered in a subset of prostate cancers (PCs) and a recent study suggested that time to
biochemical recurrence following prostatectomy correlated with the degree of hMSH2
immunohistochemical staining. We compared hMSH2 expression and survival in clinically
organ confined PC. MATERIALS AND METHODS:: A prostate tissue microarray was …
misincorporated nucleotides formed during DNA replication. Mismatch repair expression is
altered in a subset of prostate cancers (PCs) and a recent study suggested that time to
biochemical recurrence following prostatectomy correlated with the degree of hMSH2
immunohistochemical staining. We compared hMSH2 expression and survival in clinically
organ confined PC. MATERIALS AND METHODS:: A prostate tissue microarray was …