Kit and Scl regulation of hematopoietic stem cells
S Rojas-Sutterlin, E Lecuyer… - Current opinion in …, 2014 - journals.lww.com
S Rojas-Sutterlin, E Lecuyer, T Hoang
Current opinion in hematology, 2014•journals.lww.comKnowledge of the regulatory mechanisms that favor self-renewal divisions or a lineage
determination process is central to the design of strategies to expand HSCs for the purpose
of cell therapy. In addition, transcriptome and phosphoproteome analyses of erythroblasts in
polycythemia vera identified lower SCL expression and hypophosphorylated KIT,
suggesting that the KIT–SCL loop is relevant to the pathophysiology of human blood
disorders as well.
determination process is central to the design of strategies to expand HSCs for the purpose
of cell therapy. In addition, transcriptome and phosphoproteome analyses of erythroblasts in
polycythemia vera identified lower SCL expression and hypophosphorylated KIT,
suggesting that the KIT–SCL loop is relevant to the pathophysiology of human blood
disorders as well.
Summary
Knowledge of the regulatory mechanisms that favor self-renewal divisions or a lineage determination process is central to the design of strategies to expand HSCs for the purpose of cell therapy. In addition, transcriptome and phosphoproteome analyses of erythroblasts in polycythemia vera identified lower SCL expression and hypophosphorylated KIT, suggesting that the KIT–SCL loop is relevant to the pathophysiology of human blood disorders as well.
Lippincott Williams & Wilkins