[HTML][HTML] Novel biological insights in T-cell acute lymphoblastic leukemia
K Durinck, S Goossens, S Peirs, A Wallaert… - Experimental …, 2015 - Elsevier
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of blood cancer that
accounts for about 15% of pediatric and 25% of adult acute lymphoblastic leukemia (ALL)
cases. It is considered as a paradigm for the multistep nature of cancer initiation and
progression. Genetic and epigenetic reprogramming events, which transform T-cell
precursors into malignant T-ALL lymphoblasts, have been extensively characterized over
the past decade. Despite our comprehensive understanding of the genomic landscape of …
accounts for about 15% of pediatric and 25% of adult acute lymphoblastic leukemia (ALL)
cases. It is considered as a paradigm for the multistep nature of cancer initiation and
progression. Genetic and epigenetic reprogramming events, which transform T-cell
precursors into malignant T-ALL lymphoblasts, have been extensively characterized over
the past decade. Despite our comprehensive understanding of the genomic landscape of …