Targeting aberrant cancer metabolism–The role of sirtuins

R Kleszcz, J Paluszczak, W Baer-Dubowska - Pharmacological Reports, 2015 - Elsevier
Cancer cells, as opposed to normal cells, generate energy by increasing aerobic glycolysis,
which is a phenomenon called “the Warburg effect”. An altered energy metabolism
supporting continuous cell growth and proliferation was pointed to as the new “hallmark” of
cancer cells. Several hypotheses have been proposed to explain the maintenance of this
seemingly wasteful catabolic state. The epigenetic mechanisms which depend on the
covalent modifications of both DNA and histones have recently emerged as important …