[HTML][HTML] The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization
NY Yang, EB Pasquale, LB Owen, IM Ethell - Journal of biological chemistry, 2006 - ASBMB
Several studies have reported the up-regulation of EphB receptor-tyrosine kinases and
ephrin-B ligands in a variety of tumors, suggesting a functional relation between
EphB/ephrin-B signaling and tumor progression. The ability of the EphB receptors to
regulate cell migration and promote angiogenesis likely contributes to tumor progression
and metastasis. Here we show that EphB receptors, and especially EphB4, regulate the
migration of murine melanoma cells. Highly malignant melanoma cells express the highest …
ephrin-B ligands in a variety of tumors, suggesting a functional relation between
EphB/ephrin-B signaling and tumor progression. The ability of the EphB receptors to
regulate cell migration and promote angiogenesis likely contributes to tumor progression
and metastasis. Here we show that EphB receptors, and especially EphB4, regulate the
migration of murine melanoma cells. Highly malignant melanoma cells express the highest …