Cellular expression of tumour necrosis factor-α and interferon-γ in the liver biopsies of children with chronic liver disease
MJ Hussain, A Mustafa, H Gallati, AP Mowat… - Journal of …, 1994 - Elsevier
The liver biopsies of patients with autoimmune liver diseases have a dense portal tract
mononuclear cell infiltrate. To investigate whether these cells produce tumour necrosis
factor-α and interferon-γ, cytokines which could be involved in the autoimmune attack
through a direct cytopathic effect and/or through induction/enhancement of major
histocompatibility complex antigen expression, we immunohistochemically stained cryostat
liver sections from 21 children with autoimmune liver disease and from 15 children with …
mononuclear cell infiltrate. To investigate whether these cells produce tumour necrosis
factor-α and interferon-γ, cytokines which could be involved in the autoimmune attack
through a direct cytopathic effect and/or through induction/enhancement of major
histocompatibility complex antigen expression, we immunohistochemically stained cryostat
liver sections from 21 children with autoimmune liver disease and from 15 children with …