SPARCL1 expression increases with preoperative radiation therapy and predicts better survival in rectal cancer patients

A Kotti, A Holmqvist, M Albertsson, XF Sun - International Journal of …, 2014 - Elsevier
Purpose The secreted protein acidic and rich in cysteine-like 1 (SPARCL1) is expressed in
various normal tissues and many types of cancers. The function of SPARCL1 and its
relationship to a patient's prognosis have been studied, whereas its relationship to radiation
therapy (RT) is not known. Our aim was to investigate the expression of SPARCL1 in rectal
cancer patients who participated in a clinical trial of preoperative RT. Methods and Materials
The study included 136 rectal cancer patients who were randomized to undergo …