Intraperitoneal therapy for peritoneal cancer

Z Lu, J Wang, MG Wientjes, JLS Au - Future oncology, 2010 - Future Medicine
Z Lu, J Wang, MG Wientjes, JLS Au
Future oncology, 2010Future Medicine
Cancers originating from organs in the peritoneal cavity (eg, ovarian, pancreatic, colorectal,
gastric and liver) account for approximately 250,000 new cancer cases annually in the USA.
Peritoneal metastases are common owing to locoregional spread and distant metastases of
extraperitoneal cancers. A logical treatment is intraperitoneal therapy, as multiple studies
have shown significant targeting advantage for this treatment, including significant survival
benefits in stage III, surgically debulked ovarian cancer patients. However, the clinical use of …
Cancers originating from organs in the peritoneal cavity (e.g., ovarian, pancreatic, colorectal, gastric and liver) account for approximately 250,000 new cancer cases annually in the USA. Peritoneal metastases are common owing to locoregional spread and distant metastases of extraperitoneal cancers. A logical treatment is intraperitoneal therapy, as multiple studies have shown significant targeting advantage for this treatment, including significant survival benefits in stage III, surgically debulked ovarian cancer patients. However, the clinical use of intraperitoneal therapy has been limited, in part, by toxicity, owing to the use of indwelling catheters or high drug exposure, by inadequate drug penetration into bulky tumors (>1 cm) and by the lack of products specifically designed and approved for intraperitoneal treatments. This article provides an overview on the background of peritoneal metastasis, clinical research on intraperitoneal therapy, the pharmacokinetic basis of drug delivery in intraperitoneal therapy and our development of drug-loaded tumor-penetrating microparticles.
Future Medicine