Scleroderma and the subcutaneous tissue
R Fleischmajer, V Damiano, A Nedwich - Science, 1971 - science.org
R Fleischmajer, V Damiano, A Nedwich
Science, 1971•science.orgmanifestations, numerous histochemi- Page 1 iting factor in the synthesis of dopamine and
norepinephrine. Rats are born with only 1 5 percent and 30 percent of the normal adultamounts
of brain dopamine and brain norepinephrine, respectively (22). A deficicncy in the tyrosine
available for the biosynthesis of catecholamines might alter the mechanisms that are
responsi'hie for the complex regulation of these neurotransmitters. It is possible that some of the
physiological and behavioral sequellae of early proteincalorie mailnutrition result from the …
norepinephrine. Rats are born with only 1 5 percent and 30 percent of the normal adultamounts
of brain dopamine and brain norepinephrine, respectively (22). A deficicncy in the tyrosine
available for the biosynthesis of catecholamines might alter the mechanisms that are
responsi'hie for the complex regulation of these neurotransmitters. It is possible that some of the
physiological and behavioral sequellae of early proteincalorie mailnutrition result from the …
Our study revealed that as observed with both light and electron microscopy the most specific abnormality in scleroderma skin is the replacement of the subcutaneous tissue by markedly abnormal connective tissue.
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