[HTML][HTML] Regulation of TMEM16A chloride channel properties by alternative splicing
L Ferrera, A Caputo, I Ubby, E Bussani… - Journal of biological …, 2009 - ASBMB
Expression of TMEM16A protein is associated with the activity of Ca 2+-activated Cl−
channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the
generation of multiple isoforms. We have determined the pattern of splicing and assessed
the functional properties of the corresponding TMEM16A variants. We found three
alternative exons, 6b, 13, and 15, coding for segments of 22, 4, and 26 amino acids,
respectively, which are differently spliced in human organs. By patch clamp experiments on …
channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the
generation of multiple isoforms. We have determined the pattern of splicing and assessed
the functional properties of the corresponding TMEM16A variants. We found three
alternative exons, 6b, 13, and 15, coding for segments of 22, 4, and 26 amino acids,
respectively, which are differently spliced in human organs. By patch clamp experiments on …