Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance
L Menard, T Cantaert, N Chamberlain… - Journal of allergy and …, 2014 - Elsevier
Background Signaling lymphocytic activation molecule (SLAM)–associated protein (SAP)
can mediate the function of SLAM molecules, which have been proposed to be involved in
the development of autoimmunity in mice. Objective We sought to determine whether the
SLAM/SAP pathway regulates the establishment of human B-cell tolerance and what
mechanisms of B-cell tolerance could be affected by SAP deficiency. Methods We tested the
reactivity of antibodies isolated from single B cells from SAP-deficient patients with X-linked …
can mediate the function of SLAM molecules, which have been proposed to be involved in
the development of autoimmunity in mice. Objective We sought to determine whether the
SLAM/SAP pathway regulates the establishment of human B-cell tolerance and what
mechanisms of B-cell tolerance could be affected by SAP deficiency. Methods We tested the
reactivity of antibodies isolated from single B cells from SAP-deficient patients with X-linked …