Regulation of nuclear processes by inositol polyphosphates

JD York - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2006 - Elsevier
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2006Elsevier
Inositide signaling pathways represent a multifaceted ensemble of cellular switches capable
of regulating a number of processes, for example, intracellular calcium release, membrane
trafficking, chemotaxis, ion channel activity and several nuclear functions. Over 30 inositide
messengers are found in eukaryotic cells that may be grouped into two classes:(1) inositol
lipids, phosphatidylinositols or phosphoinositides (PIPs) and (2) water-soluble inositol
polyphosphates (IPs). This review will focus on inositol polyphosphate kinases (IPK) and …
Inositide signaling pathways represent a multifaceted ensemble of cellular switches capable of regulating a number of processes, for example, intracellular calcium release, membrane trafficking, chemotaxis, ion channel activity and several nuclear functions. Over 30 inositide messengers are found in eukaryotic cells that may be grouped into two classes: (1) inositol lipids, phosphatidylinositols or phosphoinositides (PIPs) and (2) water-soluble inositol polyphosphates (IPs). This review will focus on inositol polyphosphate kinases (IPK) and inositol pyrophosphate synthases (IPS) responsible for the cellular production of IP4, IP5 IP6 and PP-IPs. Of interest, IPK and IPS proteins localize, in part, within the nucleus and their activities are necessary for proper regulation of gene expression, mRNA export, DNA repair and telomere maintenance. The breadth of nuclear processes regulated and the evolutionary conservation of the genes involved in their synthesis have sparked renewed interest in inositide messengers derived from sequential phosphorylation of inositol 1,4,5-trisphosphate.
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