[HTML][HTML] Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity
MP Gaidhu, A Frontini, S Hung, K Pistor, S Cinti… - Journal of lipid …, 2011 - ASBMB
This study investigated the effect of chronic AMP-kinase (AMPK) activation with 5-
aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) on white adipose tissue
(WAT) metabolism and the implications for visceral (VC) and subcutaneous (SC) adiposity,
whole body-energy homeostasis, and hypothalamic leptin sensitivity. Male Wistar rats
received daily single intraperitoneal injections of either saline or AICAR (0.7 g/kg body
weight) for 4 and 8 weeks and were pair-fed throughout the study. AICAR-treated rats had …
aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) on white adipose tissue
(WAT) metabolism and the implications for visceral (VC) and subcutaneous (SC) adiposity,
whole body-energy homeostasis, and hypothalamic leptin sensitivity. Male Wistar rats
received daily single intraperitoneal injections of either saline or AICAR (0.7 g/kg body
weight) for 4 and 8 weeks and were pair-fed throughout the study. AICAR-treated rats had …