The role of Rab 27a in the regulation of neutrophil function

SD Catz - Cellular microbiology, 2014 - Wiley Online Library
SD Catz
Cellular microbiology, 2014Wiley Online Library
Neutrophils are central regulators of the innate immune response and help shape the
adaptive immune response. Malfunction and unregulated neutrophil activation leads to
disease and inflammation. During the host response to infection, neutrophils display several
mechanisms of defense mediated by their arsenal of granular proteins. Regulation of
granular trafficking, docking and fusion is at the core of the neutrophil defense response to
pathogens. The small GTPase Rab 27a has emerged as a central regulator of the neutrophil …
Summary
Neutrophils are central regulators of the innate immune response and help shape the adaptive immune response. Malfunction and unregulated neutrophil activation leads to disease and inflammation. During the host response to infection, neutrophils display several mechanisms of defense mediated by their arsenal of granular proteins. Regulation of granular trafficking, docking and fusion is at the core of the neutrophil defense response to pathogens. The small GTPase Rab27a has emerged as a central regulator of the neutrophil response through its tight control of vesicular trafficking and degranulation. This review focuses on the latest research that has led to the characterization of Rab27a as an essential regulator of neutrophil function.
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