Short term high fat feeding in rats results specifically in hepatic fat accumulation and
provides a model of non-alcoholic fatty liver disease in which to study the mechanism of
hepatic insulin resistance. Short term fat feeding (FF) caused a∼ 3-fold increase in liver
triglyceride and total fatty acyl-CoA content without any significant increase in visceral or
skeletal muscle fat content. Suppression of endogenous glucose production (EGP) by
insulin was diminished in the FF group, despite normal basal EGP and insulin-stimulated …