[HTML][HTML] Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

TK Hazra, YW Kow, Z Hatahet, B Imhoff… - Journal of Biological …, 2002 - ASBMB
Two candidate human orthologs ofEscherichia coli MutM/Nei were recently identified in the
human genome database, and one of these, NEH1, was characterized earlier (Hazra, TK,
Izumi, T., Boldogh, I., Imhoff, B., Kow, YW, Jaruga, P., and Dizdaroglu, M.(2002) Proc. Natl.
Acad. Sci. USA 99, 3523–3528). Here we report characterization of the second protein,
originally named NEH2 and now renamed NEIL2 (Nei-like). The 37-kDa wild-type NEIL2
expressed in and purified from E. coli has DNA glycosylase/AP lyase activity, primarily for …