Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes
A Ho, SF Dowdy - Current opinion in genetics & development, 2002 - Elsevier
A Ho, SF Dowdy
Current opinion in genetics & development, 2002•ElsevierProgression of resting quiescent G0 cells into early G1 and transition across the restriction
point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor
genes regulating these transitions are targeted during oncogenesis. Recent work has
underscored the importance of the G0 to early G1 transition and metabolism to neoplastic
cells.
point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor
genes regulating these transitions are targeted during oncogenesis. Recent work has
underscored the importance of the G0 to early G1 transition and metabolism to neoplastic
cells.
Progression of resting quiescent G0 cells into early G1 and transition across the restriction point are highly regulated processes. Mutation of proto-oncogenes and tumor suppressor genes regulating these transitions are targeted during oncogenesis. Recent work has underscored the importance of the G0 to early G1 transition and metabolism to neoplastic cells.
Elsevier