[HTML][HTML] Physiological and pharmacological implications of AT1 versus AT2 receptors
O Chung, H Kühl, M Stoll, T Unger - Kidney International, 1998 - Elsevier
Physiological and pharmacological implications of AT 1 versus AT 2 receptors. Angiotensin
II (Ang II) has diverse physiological actions that lead, for instance, to increases in
extracellular volume and peripheral vascular resistance and blood pressure, and it has also
been implicated in the regulation of cell growth and differentiation. Molecular cloning and
pharmacological studies have defined two major classes of Ang II receptors, designated AT
1 and AT 2. Most effects of Ang II are mediated by AT 1 receptors. Much less is known about …
II (Ang II) has diverse physiological actions that lead, for instance, to increases in
extracellular volume and peripheral vascular resistance and blood pressure, and it has also
been implicated in the regulation of cell growth and differentiation. Molecular cloning and
pharmacological studies have defined two major classes of Ang II receptors, designated AT
1 and AT 2. Most effects of Ang II are mediated by AT 1 receptors. Much less is known about …
Physiologic and pharmacologic implications of AT1 versus AT2 receptors.
O Chung, M Stoll, T Unger - Blood pressure. Supplement, 1996 - europepmc.org
The renin-angiotensin system (RAS) is an important factor in the pathogenesis of
cardiovascular diseases, including hypertension and congestive heart failure. The RAS also
contributes to media hypertrophy and neointima formation. The recent development of
specific, highly selective, nonpeptide angiotensin II (A II)-receptor ligands/antagonists was
the basis for the identification of the A II-receptor subtypes, AT1 and AT2, which display a
heterogeneous distribution. Virtually all known physiologic actions of A II have been …
cardiovascular diseases, including hypertension and congestive heart failure. The RAS also
contributes to media hypertrophy and neointima formation. The recent development of
specific, highly selective, nonpeptide angiotensin II (A II)-receptor ligands/antagonists was
the basis for the identification of the A II-receptor subtypes, AT1 and AT2, which display a
heterogeneous distribution. Virtually all known physiologic actions of A II have been …