[HTML][HTML] Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural …
CA Welsch, LWA Roth, JF Goetschy… - Journal of Biological …, 2004 - ASBMB
Sphingolipids are signaling molecules that influence diverse cellular functions from control
of the cell cycle to degradation of plasma membrane proteins. The synthetic sphingolipid-
like compound FTY720 is an immunomodulating agent in clinical trials for transplant graft
maintenance. In this report, we compare the effects of the natural yeast sphingolipid
phytosphingosine with FTY720 in Saccharomyces cerevisiae. We show that the multicopy
suppressor genes that induce growth resistance to FTY720 also confer resistance to growth …
of the cell cycle to degradation of plasma membrane proteins. The synthetic sphingolipid-
like compound FTY720 is an immunomodulating agent in clinical trials for transplant graft
maintenance. In this report, we compare the effects of the natural yeast sphingolipid
phytosphingosine with FTY720 in Saccharomyces cerevisiae. We show that the multicopy
suppressor genes that induce growth resistance to FTY720 also confer resistance to growth …