[HTML][HTML] Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-κB-dependent pathway

J Fu, MB Taubman - Journal of biological chemistry, 2010 - ASBMB
The egg-laying abnormal-9 (EGLN) prolyl hydroxylases have been shown to regulate the
stability and thereby the activity of the α subunits of hypoxia-inducible factor (HIF) through its
ability to catalyze their hydroxylation. We have previously shown that EGLN3 promotes
differentiation of C2C12 skeletal myoblasts. However, the mechanism underlying this effect
remains to be fully elucidated. Here, we report that exposure of C2C12 cells to dimethyl
oxalylglycine (DMOG), desferrioxamine, and hypoxia, all inhibitors of prolyl hydroxylase …