Uncontrolled or non-resolving inflammation underpins a range of disease states including
rheumatoid arthritis, inflammatory bowel disease and atherosclerosis. Hypoxia is a
prominent feature of chronically inflamed tissues. This is due to elevated oxygen
consumption by highly metabolically active inflamed resident cells and activated infiltrating
immunocytes, as well as diminished oxygen supply due to vascular dysfunction. Tissue
hypoxia can have a significant impact upon inflammatory signaling pathways in immune and …