The prediction of radiotherapy toxicity using single nucleotide polymorphism− based models: A step toward prevention
SL Kerns, S Kundu, JH Oh, SK Singhal… - Seminars in radiation …, 2015 - Elsevier
Radiotherapy is a mainstay of cancer treatment, used in either a curative or palliative
manner to treat approximately 50% of patients with cancer. Normal tissue toxicity limits the
doses used in standard radiation therapy protocols and impedes improvements in
radiotherapy efficacy. Damage to surrounding normal tissues can produce reactions ranging
from bothersome symptoms that negatively affect quality of life to severe life-threatening
complications. Improved ways of predicting, before treatment, the risk for development of …
manner to treat approximately 50% of patients with cancer. Normal tissue toxicity limits the
doses used in standard radiation therapy protocols and impedes improvements in
radiotherapy efficacy. Damage to surrounding normal tissues can produce reactions ranging
from bothersome symptoms that negatively affect quality of life to severe life-threatening
complications. Improved ways of predicting, before treatment, the risk for development of …