Pharmacological stabilization of hypoxia-inducible factor (HIF) through prolyl hydroxylase
(PHD) inhibition limits mucosal damage associated with models of murine colitis. However,
little is known about how PHD inhibitors (PHDi) influence systemic immune function during
mucosal inflammation or the relative importance of immunological changes to mucosal
protection. We hypothesized that PHDi enhances systemic innate immune responses to
colitis-associated bacteremia. Mice with colitis induced by trinitrobenzene sulfonic acid were …