[HTML][HTML] Identification and subcellular localization of the subunits of L-type calcium channels and adenylyl cyclase in cardiac myocytes
The properties of cardiac L-type channels have been well characterized
electrophysiologically, and many such studies have demonstrated that the channels are
regulated by a cAMP-dependent pathway. However, the subunit composition of native
cardiac L-type calcium channels has not been completely defined. Furthermore, a very
important question exists regarding the status of the C-terminal domain of the pore-forming α
1 subunit, as this domain has the potential to be the target of protein kinases but may be …
electrophysiologically, and many such studies have demonstrated that the channels are
regulated by a cAMP-dependent pathway. However, the subunit composition of native
cardiac L-type calcium channels has not been completely defined. Furthermore, a very
important question exists regarding the status of the C-terminal domain of the pore-forming α
1 subunit, as this domain has the potential to be the target of protein kinases but may be …