[HTML][HTML] Relocalization of STIM1 for activation of store-operated Ca2+ entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca2+ store
HL Ong, X Liu, K Tsaneva-Atanasova, BB Singh… - Journal of biological …, 2007 - ASBMB
STIM1 (stromal interacting molecule 1), an endoplasmic reticulum (ER) protein that controls
store-operated Ca 2+ entry (SOCE), redistributes into punctae at the cell periphery after
store depletion. This redistribution is suggested to have a causal role in activation of SOCE.
However, whether peripheral STIM1 punctae that are involved in regulation of SOCE are
determined by depletion of peripheral or more internal ER has not yet been demonstrated.
Here we show that Ca 2+ depletion in subplasma membrane ER is sufficient for peripheral …
store-operated Ca 2+ entry (SOCE), redistributes into punctae at the cell periphery after
store depletion. This redistribution is suggested to have a causal role in activation of SOCE.
However, whether peripheral STIM1 punctae that are involved in regulation of SOCE are
determined by depletion of peripheral or more internal ER has not yet been demonstrated.
Here we show that Ca 2+ depletion in subplasma membrane ER is sufficient for peripheral …