[HTML][HTML] Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein
RG Lee, W Fu, MJ Graham, AE Mullick, D Sipe… - Journal of lipid …, 2013 - ASBMB
Therapeutic agents that suppress apolipoprotein B (apoB) and microsomal triglyceride
transfer protein (MTP) levels/activity are being developed in the clinic to benefit patients who
are unable to reach target LDL-C levels with maximally tolerated lipid-lowering drugs. To
compare and contrast the metabolic consequences of reducing these targets, murine-
specific apoB or MTP antisense oligonucleotides (ASOs) were administered to chow-fed and
high fat-fed C57BL/6 or to chow-fed and Western diet-fed LDLr−/− mice for periods ranging …
transfer protein (MTP) levels/activity are being developed in the clinic to benefit patients who
are unable to reach target LDL-C levels with maximally tolerated lipid-lowering drugs. To
compare and contrast the metabolic consequences of reducing these targets, murine-
specific apoB or MTP antisense oligonucleotides (ASOs) were administered to chow-fed and
high fat-fed C57BL/6 or to chow-fed and Western diet-fed LDLr−/− mice for periods ranging …