Macrophage-mediated inflammation in metabolic disease

A Chawla, KD Nguyen, YPS Goh - Nature Reviews Immunology, 2011 - nature.com
A Chawla, KD Nguyen, YPS Goh
Nature Reviews Immunology, 2011nature.com
Metabolism and immunity are two fundamental systems of metazoans. The presence of
immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing
crosstalk between these two regulatory systems. Here, we discuss how changes in the
recruitment and activation of macrophages contribute to metabolic homeostasis. In
particular, we focus our discussion on the pathogenic and protective functions of classically
and alternatively activated macrophages, respectively, in experimental models of obesity …
Abstract
Metabolism and immunity are two fundamental systems of metazoans. The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two regulatory systems. Here, we discuss how changes in the recruitment and activation of macrophages contribute to metabolic homeostasis. In particular, we focus our discussion on the pathogenic and protective functions of classically and alternatively activated macrophages, respectively, in experimental models of obesity and metabolic disease.
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