[HTML][HTML] Hypoxia enhances lipid uptake in macrophages: role of the scavenger receptors Lox1, SRA, and CD36
M Crucet, SJA Wüst, P Spielmann, TF Lüscher… - Atherosclerosis, 2013 - Elsevier
OBJECTIVES: The core of advanced atherosclerotic plaques turns hypoxic as the arterial
wall thickens and oxygen diffusion capacity becomes impaired. Macrophage-derived foam
cells play a pivotal role in atherosclerotic plaque formation by expressing scavenger
receptors that regulate lipid uptake. However, the role of hypoxia in scavenger receptor
regulation remains incompletely understood. METHODS AND RESULTS: Using RT-qPCR,
flow cytometry and immunoblotting, we found that mRNA and protein expression levels of …
wall thickens and oxygen diffusion capacity becomes impaired. Macrophage-derived foam
cells play a pivotal role in atherosclerotic plaque formation by expressing scavenger
receptors that regulate lipid uptake. However, the role of hypoxia in scavenger receptor
regulation remains incompletely understood. METHODS AND RESULTS: Using RT-qPCR,
flow cytometry and immunoblotting, we found that mRNA and protein expression levels of …