Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
A Vieira-de-Abreu, RA Campbell, AS Weyrich… - Seminars in …, 2012 - Springer
A Vieira-de-Abreu, RA Campbell, AS Weyrich, GA Zimmerman
Seminars in immunopathology, 2012•SpringerPlatelets are chief effector cells in hemostasis. In addition, however, their specializations
include activities and intercellular interactions that make them key effectors in inflammation
and in the continuum of innate and adaptive immunity. This review focuses on the immune
features of human platelets and platelets from experimental animals and on interactions
between inflammatory, immune, and hemostatic activities of these anucleate but complex
and versatile cells. The experimental findings and evidence for physiologic immune …
include activities and intercellular interactions that make them key effectors in inflammation
and in the continuum of innate and adaptive immunity. This review focuses on the immune
features of human platelets and platelets from experimental animals and on interactions
between inflammatory, immune, and hemostatic activities of these anucleate but complex
and versatile cells. The experimental findings and evidence for physiologic immune …
Abstract
Platelets are chief effector cells in hemostasis. In addition, however, their specializations include activities and intercellular interactions that make them key effectors in inflammation and in the continuum of innate and adaptive immunity. This review focuses on the immune features of human platelets and platelets from experimental animals and on interactions between inflammatory, immune, and hemostatic activities of these anucleate but complex and versatile cells. The experimental findings and evidence for physiologic immune functions include previously unrecognized biologic characteristics of platelets and are paralleled by new evidence for unique roles of platelets in inflammatory, immune, and thrombotic diseases.
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