Elevated plasma angiopoietin-2 levels are associated with fluid overload, organ dysfunction, and mortality in human septic shock
J Fisher, JJ Douglas, A Linder, JH Boyd… - Critical Care …, 2016 - journals.lww.com
Objectives: Angiopoietins modulate endothelial permeability via endothelial cell junctions.
Angiopoietin-2 blocks the angiopoietin-1/Tie-2 interaction that stabilizes these junctions, and
elevated plasma angiopoietin-2 levels are associated with vascular leakage. We
hypothesized that plasma angiopoietin-1 and angiopoietin-2 levels are associated with
indirect markers of increased vascular permeability, organ dysfunction, mortality, and
plasma proinflammatory cytokine levels in human septic shock. Design: Multicenter …
Angiopoietin-2 blocks the angiopoietin-1/Tie-2 interaction that stabilizes these junctions, and
elevated plasma angiopoietin-2 levels are associated with vascular leakage. We
hypothesized that plasma angiopoietin-1 and angiopoietin-2 levels are associated with
indirect markers of increased vascular permeability, organ dysfunction, mortality, and
plasma proinflammatory cytokine levels in human septic shock. Design: Multicenter …