Zymosan—induced arthritis

EC Keystone, HU Schorlemmer… - … : Official Journal of the …, 1977 - Wiley Online Library
EC Keystone, HU Schorlemmer, C Pope, AC Allison
Arthritis & Rheumatism: Official Journal of the American College …, 1977Wiley Online Library
Zymosan particles, which are able to activate complement by the alternative pathway and to
induce enzyme secretion from macrophages, were injected into knee joints of mice. After
various time intervals, synovia were assessed histologically for various markers of
inflammation. Within 7 days after intraarticular injection of zymosan, a chronic inflammatory
arthritis with mononuclear cell infiltration, synovial hypertrophy and pannus formation was
observed. Latex particles, which do not activate complement or macrophages, produced …
Abstract
Zymosan particles, which are able to activate complement by the alternative pathway and to induce enzyme secretion from macrophages, were injected into knee joints of mice. After various time intervals, synovia were assessed histologically for various markers of inflammation. Within 7 days after intraarticular injection of zymosan, a chronic inflammatory arthritis with mononuclear cell infiltration, synovial hypertrophy and pannus formation was observed. Latex particles, which do not activate complement or macrophages, produced only mild, transient inflammatory reactions.
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