[HTML][HTML] Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis
R Reinehr, S Becker, A Eberle, S Grether-Beck… - Journal of biological …, 2005 - ASBMB
CD95 ligand (CD95L) triggers a rapid formation of reactive oxygen species (ROS) as an
upstream event of CD95 activation and apoptosis induction in rat hepatocytes. This ROS
response was sensitive to inhibition by diphenyleneiodonium, apocynin, and neopterin,
suggestive of an involvement of NADPH oxidases. In line with this, hepatocytes expressed
mRNAs not only of the phagocyte gp91 phox (Nox 2), but also of the homologs Nox 1 and 4
and Duox 1 and 2, as well as the regulatory subunit p47 phox. gp91 phox (Nox 2) and p47 …
upstream event of CD95 activation and apoptosis induction in rat hepatocytes. This ROS
response was sensitive to inhibition by diphenyleneiodonium, apocynin, and neopterin,
suggestive of an involvement of NADPH oxidases. In line with this, hepatocytes expressed
mRNAs not only of the phagocyte gp91 phox (Nox 2), but also of the homologs Nox 1 and 4
and Duox 1 and 2, as well as the regulatory subunit p47 phox. gp91 phox (Nox 2) and p47 …