Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments
Huntingtin is phosphorylated on serine-421 (S421) by the pro-survival signaling protein
kinases Akt and SGK. Phosphorylation of huntingtin at S421 is variable in different regions of
the brain with the lowest levels observed in the striatum, which is further reduced by the
mutation for Huntington disease (HD). Cleavage of huntingtin by caspase-6 at amino acid
586 is a crucial event in the pathogenesis of HD. Nuclear localization of huntingtin is also an
important marker of HD and preventing or delaying its nuclear accumulation is protective in …
kinases Akt and SGK. Phosphorylation of huntingtin at S421 is variable in different regions of
the brain with the lowest levels observed in the striatum, which is further reduced by the
mutation for Huntington disease (HD). Cleavage of huntingtin by caspase-6 at amino acid
586 is a crucial event in the pathogenesis of HD. Nuclear localization of huntingtin is also an
important marker of HD and preventing or delaying its nuclear accumulation is protective in …