Aminoglycoside ototoxicity in the chick (Gallus domesticus) inner ear: I. The effects of kanamycin and netilmicin on the basilar papilla
CD Fermin, M Igarashi - American Journal of Otolaryngology, 1983 - Elsevier
A single dose (100 mg/kg of egg weight) of kanamycin or netilmicin was injected into the
yolk sacs of 7-day-old chick (Gallus domesticus) embryos. Embryos were colledted every 24
hours and processed for light and transmission electron microscopy. Morphologic study of
the medial basilar papilla disclosed that both kanamycin and netilmicin are toxic to the hair
cells in this region. Intoxication was manifested by an increased number of dense
osmiophilic bodies, swollen mitochondria, agglomerated chromatin, and occasional …
yolk sacs of 7-day-old chick (Gallus domesticus) embryos. Embryos were colledted every 24
hours and processed for light and transmission electron microscopy. Morphologic study of
the medial basilar papilla disclosed that both kanamycin and netilmicin are toxic to the hair
cells in this region. Intoxication was manifested by an increased number of dense
osmiophilic bodies, swollen mitochondria, agglomerated chromatin, and occasional …