Distinctive patterns of chromatin modification control gene expression and define cellular
identity during development and cell differentiation. Polycomb repressive complex 2 (PRC2),
the sole mammalian enzymatic complex capable of establishing gene-repressive high-
degree methylation of histone H3 at lysine 27 (H3K27), plays crucial roles in regulation of
normal and malignant hematopoiesis. Recently, increasing evidence has indicated that
recurrent gain-of-function mutation and overexpression of EZH2, the catalytic subunit of …