Sphingomyelinase-like phosphodiesterase 3b expression levels determine podocyte injury phenotypes in glomerular disease
TH Yoo, CE Pedigo, J Guzman… - Journal of the …, 2015 - journals.lww.com
Diabetic kidney disease (DKD) is the most common cause of ESRD in the United States.
Podocyte injury is an important feature of DKD that is likely to be caused by circulating
factors other than glucose. Soluble urokinase plasminogen activator receptor (suPAR) is a
circulating factor found to be elevated in the serum of patients with FSGS and causes
podocyte αVβ 3 integrin-dependent migration in vitro. Furthermore, αVβ 3 integrin activation
occurs in association with decreased podocyte-specific expression of acid …
Podocyte injury is an important feature of DKD that is likely to be caused by circulating
factors other than glucose. Soluble urokinase plasminogen activator receptor (suPAR) is a
circulating factor found to be elevated in the serum of patients with FSGS and causes
podocyte αVβ 3 integrin-dependent migration in vitro. Furthermore, αVβ 3 integrin activation
occurs in association with decreased podocyte-specific expression of acid …