[HTML][HTML] Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2)

R Larue, K Gupta, C Wuensch, N Shkriabai… - Journal of Biological …, 2012 - ASBMB
Transportin 3 (TNPO3 or TRN-SR2) has been shown to be an important cellular factor for
early steps of lentiviral replication. However, separate studies have implicated distinct
mechanisms for TNPO3 either through its interaction with HIV-1 integrase or capsid. Here
we have carried out a detailed biophysical characterization of TNPO3 and investigated its
interactions with viral proteins. Biophysical analyses including circular dichroism, analytical
ultracentrifugation, small-angle x-ray scattering, and homology modeling provide insight into …