[PDF][PDF] Metformin action: concentrations matter

L He, FE Wondisford - Cell metabolism, 2015 - cell.com
Cell metabolism, 2015cell.com
Metformin has been used for nearly a century and is now the most widely prescribed oral
anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and
controversial. One key reason may be that almost all previous studies were conducted with
supra-pharmacological concentrations (doses) of metformin, 10–100 times higher than
maximally achievable therapeutic concentrations found in patients with type 2 diabetes
mellitus.
Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10–100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.
cell.com