Identification of genes involved in tumor-like properties of embryonic stem cells
K Takahashi, T Ichisaka, S Yamanaka - Embryonic Stem Cell Protocols …, 2006 - Springer
K Takahashi, T Ichisaka, S Yamanaka
Embryonic Stem Cell Protocols: Volume 1: Isolation and Characterization, 2006•SpringerEmbryonic stem (ES) cells are pluripotent stem cells derived from preimplantation stage
embryos. ES cells proliferate infinitely while maintaining pluripotency. These properties
make them attractive sources for stem cell therapies and regenerative medicine. However,
undifferentiated ES cells produce tumors when transplanted, which may preclude their
therapeutic usage. It is largely unknown why ES cells can possess tumorigenicity without
having chromosomal abnormalities. In this chapter, we introduce the methods to identify …
embryos. ES cells proliferate infinitely while maintaining pluripotency. These properties
make them attractive sources for stem cell therapies and regenerative medicine. However,
undifferentiated ES cells produce tumors when transplanted, which may preclude their
therapeutic usage. It is largely unknown why ES cells can possess tumorigenicity without
having chromosomal abnormalities. In this chapter, we introduce the methods to identify …
Abstract
Embryonic stem (ES) cells are pluripotent stem cells derived from preimplantation stage embryos. ES cells proliferate infinitely while maintaining pluripotency. These properties make them attractive sources for stem cell therapies and regenerative medicine. However, undifferentiated ES cells produce tumors when transplanted, which may preclude their therapeutic usage. It is largely unknown why ES cells can possess tumorigenicity without having chromosomal abnormalities. In this chapter, we introduce the methods to identify genes that play roles in tumor-like properties of ES cells.
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