[HTML][HTML] Saturation Mutagenesis of the WSXWS Motif of the Erythropoietin Receptor (∗)
DJ Hilton, SS Watowich, L Katz, HF Lodish - Journal of Biological Chemistry, 1996 - ASBMB
The WSXWS motif in the extracellular domain defines members of the cytokine receptor
family, yet its role in receptor structure and function remains unresolved. To address this
question we have generated a panel of 100 mutants within the WSXWS motif of the
erythropoietin receptor, which represents all single amino acid substitutions of these five
amino acids. All mutants were synthesized at the same level; however, their passage from
the endoplasmic reticulum to the Golgi apparatus differed. Because of this, expression of …
family, yet its role in receptor structure and function remains unresolved. To address this
question we have generated a panel of 100 mutants within the WSXWS motif of the
erythropoietin receptor, which represents all single amino acid substitutions of these five
amino acids. All mutants were synthesized at the same level; however, their passage from
the endoplasmic reticulum to the Golgi apparatus differed. Because of this, expression of …