Molecular cloning of the cDNA coding sequence of IL-2 receptor-γ (γc) from human and murine forebrain: expression in the hippocampus in situ and by brain cells in …
JM Petitto, Z Huang, MK Raizada, CM Rinker… - Molecular brain …, 1998 - Elsevier
IL-2 has been implicated in various neurobiological processes of the mammalian CNS. To
understand how IL-2 acts in the brain, our lab has sought to determine the molecular
pharmacological characteristics of brain IL-2 receptors (IL-2R). The lymphocyte IL-2Rγ, an
essential subunit for IL-2 signaling, is also a common subunit (γc) for multiple immune
cytokine receptors (eg, IL-4R, IL-7R, IL-9R, IL-15R). Having previously cloned the α and β
subunits of the IL-2R heterotrimer complex from normal murine forebrain, we examined the …
understand how IL-2 acts in the brain, our lab has sought to determine the molecular
pharmacological characteristics of brain IL-2 receptors (IL-2R). The lymphocyte IL-2Rγ, an
essential subunit for IL-2 signaling, is also a common subunit (γc) for multiple immune
cytokine receptors (eg, IL-4R, IL-7R, IL-9R, IL-15R). Having previously cloned the α and β
subunits of the IL-2R heterotrimer complex from normal murine forebrain, we examined the …